Four Advanced Properties in One Material
TrelCor’s unique nanocrystalline surface structure and HCA surface composition provide distinct advantages during the bone formation process. These surface properties, along with a biomimetic porosity and dual-staged resorption, form the basis of TrelCor advanced bone grafting technology.
TrelCor is a unique bone graft material that combines four advanced bone graft properties into a single material. These properties are based on well-established scientific principles,1-4 as well as additional supporting studies conducted by Biogennix.5,6
Read about Biogennix’s in vivo cell stimulation study and in vitro bioactivity study below.
In Vivo Cell Stimulation Study
A muscle pouch implantation was conducted in sheep to confirm TrelCor’s ability to differentiate mesenchymal stem cells (MSCs) found in muscle into bone forming osteoblasts.5 TrelCor was compared directly against a standard calcium phosphate ceramic without a nanocrystalline HCA surface (generic CaP) and Bioglass.
- A significant bone formation response was seen in all TrelCor samples. Bioglass samples showed a marginal response. Bone formation in the TrelCor samples was nearly 4X higher than Bioglass.
- Results confirmed that first-generation calcium phosphate ceramics lacking advanced properties did not elicit a cellular response.
TrelCor Granule, 12-Week Histology Image (Backscattered SEM)
In Vitro Bioactivity Study
Bioactivity is an advanced bone graft property that is defined by a material’s ability to form a calcium phosphate layer when exposed to body fluid. Specifically, bioactive surfaces interact with ions in body fluid to precipitate a nanocrystalline HCA layer directly on the material.
Although TrelCor is manufactured with a nanocrystalline HCA layer, a bioactivity study was conducted to see if this layer could increase due to a bioactive surface response.6 This was an in vitro study that exposed TrelCor to a simulated body fluid solution and compared the surface response to Bioglass.
- TrelCor demonstrated a strong bioactive response when immersed in SBF. Additional nanocrystalline HCA material was deposited on the existing HCA surface.
- The bioactive layer on TrelCor was much thicker than the layer that formed on Bioglass
- Based on layer thickness, TrelCor was more bioactive than Bioglass
Day 0 TrelCor Cross-Section
Day 0 Bioglass Cross-Section
Day 14 TrelCor Cross-Section
Day 14 Bioglass Cross-Section
References 1. Zhang J. et al. J. of Tissue Eng. And Regen. Med. 11: pp. 3273-3283 (2017); 2. Duan R. et al.ACS Biomater. Sci. Eng. 4: pp. 3347-3355 (2018). 3. Spence G. et al. Key Eng. Materials Vols. 309-31: pp 207-210 (2006); 4. Hayashi K. et al. Materials Today Bio. 4: pp. 1-11 (2019); 5. Data on File: Ectopic Bone Formation Response of TrelCor in a Sheep Intramuscular Pouch Model; 6. Data on File: Evaluation of the Bioactive Response to TrelCor Bone Graft Products.
Dig Deeper into TrelCor
For a more in-depth look at the healing benefits of advanced synthetic bone grafts, download our free PDF.
You can also visit the Biogennix Blog.
