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TrelCor® Technology

Discover the advantages of advanced surface chemistry

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Bone regeneration is a cellular process that involves the interaction of osteoblasts and stem cells with the surface of a bone graft material. Studies have shown that the composition of a bone graft material can impact the bone formation response.1,2

TrelCor technology features unique, dual-phase composition that consists of a microscopically thin (~5 microns) hydroxycarbonoapatite (HCA) surface layer over a porous calcium carbonate structure. HCA is a carbonated form of calcium phosphate that closely resembles the mineral content of bone, giving it advanced osteoconductive properties.

Dual-Phase Composition

The HCA Advantage

Most ceramic-based bone grafts do not contain carbonate. The main advantage of adding carbonate to hydroxyapatite is that it allows for faster bone formation.

  • Natural bone mineral is composed of carbonated apatite. HCA is the only ceramic with a composition similar to natural bone.
  • Bone formation on HCA-covered graft materials essentially “skips” the cellular preparation phase seen with standard calcium phosphate ceramics, like HA and TCP.
  • This results in faster activation of cells and a faster bone formation process.2
Mature Bone Formation Response to HCA

Study Comparing HCA to First-Generation Materials

A 2019 independent study evaluated the bone formation response of HCA versus two other common calcium phosphate graft materials: hydroxyapatite (HA) and tricalcium phosphate (TCP).2

  • All materials were fabricated with the exact same bone graft scaffold structure and implanted into a long bone defect.
  • The results showed that significantly more bone had formed faster in the HCA group compared to the HA and TCP groups at both the 4-week and 12-week time points.
  • This was more pronounced at the earlier time-point (4-weeks) which showed that HCA resulted 4.3X more bone than TCP and 14.3X more bone than HA.
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References 1. Spence G. et al. Key Eng. Materials Vols. 309-31: pp 207-210 (2006); 2. Hayashi K. et al. Materials Today Bio. Honeycomb blocks composed of carbonate apatite, β-tricalcium phosphate, and hydroxyapatite for bone regeneration: effects of composition on biological responses. 4: pp. 1-11 (2019).

Dig Deeper into TrelCor

For a more in-depth look at the healing benefits of a bone-like HCA surface chemistry, download our free PDF.

You can also visit the Biogennix Blog.

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When you combine live cells with an advanced surface, you are optimizing the healing response. Surgeons and hospitals alike need innovative solutions with strong scientific backing which incorporate new biological technologies.

Spine SurgeonCalifornia

Products like Biogennix's advanced synthetics are really novel because of the characteristics that they have. Surgeons who are on the cutting-edge appreciate the science behind the product.


My bigger cases usually require a large amount of graft, and so the synthetics can extend the autograft I've harvested. Biogennix's [advanced synthetics] have properties that are great for bone formation, and they are universally available in large quantities. Synthetic bone grafts can take the autograft that you have and turn 20cc into 40cc. In a way, they grow the bone graft for you.

Spine SurgeonVirginia

Because the journey to great outcomes starts with great decisions.

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