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Biogennix Core Technology

osteoSPAN Granules are based on Biogennix’s innovative TrelCor technology platform which utilizes a nanocrystalline HCA surface and a biomimetic pore structure to improve bone healing. The granules are a versatile and proven bone graft product indicated for use in long bone defects, the pelvis, and the posterolateral spine (when combined with autograft).  Additionally, osteSPAN Granules (also called TrelCor Granules) are the main bone graft component of Biogennix moldable products, Morpheus and Agilon Moldable.

osteoSPAN Granules represent an advanced bone graft material with a nano-crystalline surface, and an HCA composition and interconnected pore structure that emulate human cancellous bone.  Once implanted, bone and marrow cells attach to the nano-crystalline HCA surface that completely covers the granules.  The combination of the HCA composition and nano-crystalline structure provides an enhanced surface for bone formation.  Studies have shown that osteoSPAN supports direct bone formation on its surface and becomes incorporated into a bone fusion mass, while gradually resorbing over a 6-12 month period (ideal for bone remodeling).

osteoSPAN is also available in a block form (osteoSPAN Fusion Kit) that is specifically designed for posterolateral fusion procedures.

Click for Fusion Kit info

osteoSPAN Logo

Configuration: Granules, 1-4mm in size

Chemistry: Nanocrystalline hydroxycarbanoapatite (HCA) / calcium carbonate (CC)

Architecture: Biomimetic structure similar to cancellous bone; interconnected porosity

Pore Size: 500 microns (µm)

Resorption Profile: 6-12 months

Storage and Handling: Room temperature, no reconstitution required

osteoSPAN Logo

Configuration: Granules, 1-4mm in size

Chemistry: Nanocrystalline hydroxycarbanoapatite (HCA) / calcium carbonate (CC)

Architecture: Biomimetic structure similar to cancellous bone; interconnected porosity

Pore Size: 500 microns (µm)

Resorption Profile: 6-12 months

Storage and Handling: Room temperature, no reconstitution required

osteoSPAN DIFFERENCE
osteoSPAN DIFFERENCE

Unlike other porous ceramic materials, osteoSPAN is an advanced bone graft that is actively involved in the bone healing process

• Nanocrystalline Surface

  • Nanocrystalline structure provides an optimal surface for cell attachment
  • Nanocrystalline ceramics have been shown to improve cell proliferation, and stimulate cell differentiation and function1

• Composition Similar to Bone Mineral

  • Hydroxycarbanoapatite (HCA) closely mimics the natural composition of human bone mineral
  • HCA materials have been shown to enhance the osteoconductive response2

• Biomimetic Porous Architecture

  • 100% interconnected pore structure and pore size allows bone formation throughout the entire implant
  • Pore architecture similar to cancellous bone results in an optimal combination of strength and porosity, and a structure that is resistant to crushing during implantation

References
1 – Zhang J. et al. J. of Tissue Eng. And Regen. Med. 11: pp 3273-3283 (2017); Duan R. et al. ACS Biomater. Sci. Eng. 4: pp 3347-3355 (2018)
2 – Spence G. et al. Key Eng. Materials Vols. 309-31: pp 207-210 (2006); Hayashi K. et al. Materials Today Bio. 4: pp. 1-11 (2019)

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